2021
September 21, 2021
Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest
– Dr. Kiran Rikhraj and Dr. Kerry Spearing | View Article Appraisal
May 18, 2021
Single vs Serial Measurements of Cardiac Troponin Level in the Evaluation of Patients in the Emergency Department With Suspected Acute Myocardial Infarction
– Dr. Amol Lail | View Article Appraisal
Association of Intravenous Radiocontrast With Kidney Function: A Regression Discontinuity Analysis
– Dr. Shayla Duley | View Article Appraisal
April 20, 2021
– Dr. Brandon Evtushevski & Dr. Kira Gossack-Keenan | View Article Appraisal
Elevated Blood Pressures Are Common in the Emergency Department but Are They Important? A Retrospective Cohort Study of 30,278 Adults
– Dr. Jeremy Christenson | View Article Appraisal
March 16, 2021
– Dr. J. Michael Wafler | View Article Appraisal
– Dr. Kelly Huang & Dr. Kevin Duncan | View Article Appraisal
February 17, 2021
Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding
– Dr. Kate Eppler & Dr. Colin Sedgwick | View Article Appraisal
February 16, 2021
– Dr. Xin Mei Liu | View Article Appraisal
January 19, 2021
Prediction of cerebral venous thrombosis with a new clinical score and D-dimer levels
– Dr. Ryan Kohler & Dr. Kia Dullemond | View Article Appraisal
2020
December 15, 2020
– Dr. Sam Brophy & Dr. Kiran Rikhraj | View Article Appraisal
Diagnosing acute aortic syndrome: a Canadian clinical practice guideline
– Dr. Andrew Kestler | View Article Appraisal
November 17, 2020
Safety of peripheral administration of vasopressor medications: A systematic review
– Dr. Mike De Paoli | View Article Appraisal
Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA (THALES Trial)
– Dr. Brendan Arnold | View Article Appraisal
October 20, 2020
– The HALT-IT Trial Collaborators | View Article Appraisal
-Firas Ayoub, Michael Quirke, Daniel Frith | View Article Appraisal
September 15, 2020
Race, Postoperative Complications, and Death in Apparently Healthy Children
– Olubukola O. Nafiu, Christian Mpody, Stephani S. Kim, Joshua C. Uffman and Joseph D. Tobias | View Article Appraisal
Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report
-The RECOVERY Collaborative Group | View Article Appraisal
May 19, 2020
Presenting Characteristics, Comorbidities and Outcomes Among 5700 Patients Hospitalized with COVID-19 in the New York City Area
– Safiya Richardson, Jamie S. Hirsch, Mangala Narasimhan | View Article Appraisal
-Yeming Wang, Dingyu Zhang, Prof Guanhua Du, Prof Ronghui Du, Prof Jianping Zhao, Prof Yang Jin | View Article Appraisal
February 21, 2020
Conservative versus interventional management for primary spontaneous pneumothorax in adults
– Michael Ashby, Greg Haug, Pete Mulcahy, Kathryn Ogden, Oliver Jensen. Cochrane database of systematic reviews. 06/06/2013 Volume: 2013 Issue:6. | View Article Appraisal
February 18, 2020
A Prediction Model to Identify Febrile Infants <60 Days at Low Risk of Invasive Bacterial Infection
– Paul L. Aronson, Veronika Shabanova, Eugene D. Shapiro, Marie E. Wang, Lise E. Nigrovic, Christopher M. Pruitt, Adrienne G. DePorre, Rianna C. Leazer, Sanyukta Desai, Laura F. Sartori, Richard D. Marble, Sahar N. Rooholamini, Russell J. McCulloh, Christopher Woll, Fran Balamuth, Elizabeth R. Alpern, Samir S. Shah, Derek J. Williams, Whitney L. Browning, Nipam Shah, Mark I. Neuman and for the Febrile Young Infant Research Collaborative
Pediatrics July 2019, 144 (1) e20183604; DOI: https://doi.org/10.1542/peds.2018-3604 | View Article Appraisal
January 21, 2020
Does Point-of-Care Ultrasonography Improve Clinical Outcomes in Emergency Department Patients with Undifferentiated Hypotension? An International Randomized Controlled Trial from the SHoC-ED Investigators
– Annals of Emergency Medicine, October 2018. | View Article Appraisal
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. The CRASH-3 trial collaborators.
The CRASH-3 trial collaborators. October 14, 2019. | View Article Appraisal
Archive
December 21, 2019
Three week versus six week immobilization for stable Weber B type ankle fractures: randomized, multicentre, non-inferiority trial
Kortekangas and colleagues. BMJ February 19, 2019
November 19, 2019
Does Initial Temperature in the Emergency Department Predict Outcomes in Patients Admitted for Sepsis?
Boris Khodorkovsky, Elias Youssef, Frosso Adamakos, Tiffany Cina, Amanda Falco, Lauren LaMura, Anthony Marion, Samuel Nathan, Barry Hahn. September 2018.
Defining the criteria for intubation of the patient with thermal burns, Budulak et al. Published in Burns (2018).
Jenelle H.Badulak, Michael Schurr, Angela Sauaia, Anna Ivashchenko, Erik Peltz. May 2018.
October 15, 2019
Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm by Lascarrou et al.
Jean-Baptiste Lascarrou, M.D., Hamid Merdji, M.D., Ph.D., Amélie Le Gouge, M.Sc., Gwenhael Colin, M.D., Guillaume Grillet, M.D., Patrick Girardie, M.D., Elisabeth Coupez, M.D., Pierre-François Dequin, M.D., Ph.D., Alain Cariou, M.D., Ph.D., Thierry Boulain, M.D., Noelle Brule, M.D., Jean-Pierre Frat, M.D., Ph.D., et al., for the CRICS-TRIGGERSEP Group*. Oct 2, 2019
Evaluation of out-of-hospital cardiac arrest using transesophageal echocardiography (TEE) in the emergency department.
Felipe Teran, Anthony J. Dean, Claire Centeno, Nova L. Panebianco, Amy J. Zeidan, Wilma Chan, Benjamin S. Abella.https://doi.org/10.1016/j.resuscitation.2019.02.013. April 2019.
Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis
Matthew P. Cheng, MD; Robert Stenstrom, MD, PhD; Katryn Paquette, MD; Sarah N. Stabler, PharmD; Murtaza Akhter, MD; Adam C. Davidson, MD; Marko Gavric, BSc; Alexander Lawandi, MD; Rehman Jinah, BSc; Zahid Saeed, MD; Koray Demir, MD; Kelly Huang, BSc; Amirali Mahpour, MD; Chris Shamatutu, BSc; Chelsea Caya, MSc; Jean-Marc Troquet, MD; Greg Clark, MD;
Cedric P. Yansouni, MD; and David Sweet, MD; for the FABLED Investigators* October 15, 2019.
Sept 17, 2019
CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions
Prins HJ, Duijkers R, van der Valk P, Schoorl M, Daniels JMA, van der Werf TS, Boersma WG. CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions. Eur Respir J. 2019 May 23;53(5). pii: 1802014. doi: 10.1183/13993003.02014-2018. Print 2019 May.
C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations
Butler CC, Gillespie D, White P, Bates J, Lowe R, Thomas-Jones E, Wootton M, Hood K, Phillips R, Melbye H, Llor C, Cals JWL, Naik G, Kirby N, Gal M, Riga E, Francis NA. C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations. N Engl J Med. 2019 Jul 11;381(2):111-120. doi: 10.1056/NEJMoa1803185.
Epidemiology/Biostatistics Resource Person: Dr. Corinne Hohl
June 18, 2019
Buddy taping versus splint immobilization for paediatric finger fractures: a randomized controlled trial
Weber DM, Seiler M, Subotic U, Kalisch M, Weil R. Buddy taping versus splint immobilization for paediatric finger fractures: a randomized controlled trial. J Hand Surg Eur Vol. 2019 Jan 31:1753193418822692. doi: 10.1177/1753193418822692.
Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial
Dalziel SR et al. Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial. Lancet. 2019 Apr 17. pii: S0140-6736(19)30722-6. doi: 10.1016/S0140-6736(19)30722-6.
Utility of Neuroimaging in Children Presenting to a Pediatric Emergency Department With Ataxia
Luetje M, Kannikeswaran N, Arora R, Wang B, Farooqi A, Sivaswamy L. Utility of Neuroimaging in Children Presenting to a Pediatric Emergency Department With Ataxia. Pediatr Emerg Care. 2019 May;35(5):335-340. doi: 10.1097/PEC.0000000000001823.
Epidemiology/Biostatistics Resource Person: Dr. Frank Scheuermeyer
May 21, 2019
Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation
Pluymaekers NAHA, et al. Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation. N Engl J Med. 2019 Apr 18;380(16):1499-1508. doi: 10.1056/NEJMoa1900353. Epub 2019 Mar 18.
Coronary Angiography after Cardiac Arrest without ST-Segment Elevation
Lemkes JS, et al. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation. N Engl J Med. 2019 Apr 11;380(15):1397-1407. doi: 10.1056/NEJMoa1816897.
Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis
Nath S, et al. Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis. Lancet. 2018 Mar 24;391(10126):1197-1204. doi: 10.1016/S0140-6736(17)32451-0.
Epidemiology/Biostatistics Resource Person: Dr. Rob Stenstrom
Apr. 16, 2019
Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults
Casey JC, et al. Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults. N Engl J Med. 2019 Feb 28;380(9):811-821. doi: 10.1056/NEJMoa1812405. Epub 2019 Feb 18.
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial
April MD, Oliver JJ, Davis WT, Ong D, Simon EM, Ng PC, Hunter CJ. Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Ann Emerg Med. 2018 Aug;72(2):184-193. doi: 10.1016/j.annemergmed.2018.01.016. Epub 2018 Feb 17.
Impact of scribes on emergency medicine doctors’ productivity and patient throughput: multicentre randomised trial
Walker K, et al. Impact of scribes on emergency medicine doctors’ productivity and patient throughput: multicentre randomised trial. BMJ 2019; 364 doi: https://doi.org/10.1136/bmj.l121
Epidemiology/Biostatistics Resource Person: Dr. Frank Scheuermeyer
Mar. 19, 2019
Duration of Electrocardiographic Monitoring of Emergency Department Patients with Syncope
Thiruganasambandamoorthy V, Rowe BH, Sivilotti MLA, McRae AD, Arcot K, Nemnom MJ, Huang L, Mukarram M, Krahn AD, Wells GA, Taljaard M. Duration of Electrocardiographic Monitoring of Emergency Department Patients with Syncope. Circulation. 2019 Jan 21. doi: 10.1161/CIRCULATIONAHA.118.036088.
Test Characteristics of Point-of-care Ultrasound for the Diagnosis of Retinal Detachment in the Emergency Department
Kim DJ, Francispragasam M, Docherty G, Silver B, Prager R, Lee D, Maberley D. Test Characteristics of Point-of-care Ultrasound for the Diagnosis of Retinal Detachment in the Emergency Department. Acad Emerg Med. 2019 Jan;26(1):16-22. doi: 10.1111/acem.13454. Epub 2018 Dec 17
Epidemiology/Biostatistics Resource Person: Dr. Jess Moe
Feb. 19, 2019
Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial
Moore HB, et al. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial. Lancet. 2018 Jul 28;392(10144):283-291. doi: 10.1016/S0140-6736(18)31553-8. Epub 2018 Jul 20.
Sodium bicarbonate on severe metabolic acidosis during prolonged cardiopulmonary resuscitation: a double-blind, randomized, placebo-controlled pilot study
Ahn S, Kim YJ, Sohn CH, Seo DW, Lim KS, Donnino MW, Kim WY. Sodium bicarbonate on severe metabolic acidosis during prolonged cardiopulmonary resuscitation: a double-blind, randomized, placebo-controlled pilot study. J Thorac Dis. 2018 Apr;10(4):2295-2302. doi: 10.21037/jtd.2018.03.124.
Epidemiology/Biostatistics Resource Person: Dr. John Tallon
Jan. 15, 2019
Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial
Sprigg N, et al. Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. Lancet. 2018 May 26;391(10135):2107-2115. doi: 10.1016/S0140-6736(18)31033-X. Epub 2018 May 16.
Intravenous Subdissociative-Dose Ketamine Versus Morphine for Analgesia in the Emergency Department: A Randomized Controlled Trial
Motov S, et al. Intravenous Subdissociative-Dose Ketamine Versus Morphine for Analgesia in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2015 Sep;66(3):222-229.e1. doi: 10.1016/j.annemergmed.2015.03.004. Epub 2015 Mar 26.
Epidemiology/Biostatistics Resource Person: Dr. David Barbic
Dec. 18, 2018
Validation and refinement of a clinical decision rule for the use of computed tomography in children with minor head injury in the emergency department
Osmond M, et al. Validation and refinement of a clinical decision rule for the use of computed tomography in children with minor head injury in the emergency department. CMAJ July 09, 2018 190 (27) E816-E822.
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock
Annane D et al. Hydrocortisone plus Fludrocortisone for Adults with Septic Shock. N Engl J Med. 2018 Mar 1;378(9):809-818.
Epidemiology/Biostatistics Resource Person: Dr. Frank Scheuermeyer
Nov. 20, 2018
Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
Wang H et al. Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA. 2018 Aug 28;320(8):769-778. doi: 10.1001/jama.2018.7044.
Apneic oxygenation reduces hypoxemia during endotracheal intubation in the pediatric emergency department
Vukovic AA, Hanson HR, Murphy SL, Mercurio D, Sheedy CA, Arnold DH. Apneic oxygenation reduces hypoxemia during endotracheal intubation in the pediatric emergency department. Am J Emerg Med. 2018 Apr 18. pii: S0735-6757(18)30321-8. doi: 10.1016/j.ajem.2018.04.039.
Epidemiology/Biostatistics Resource Person: Dr. Riyad Abu-Laban
Oct. 16, 2018
Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial
Zahed R, Mousavi Jazayeri MH, Naderi A, Naderpour Z, Saeedi M. Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial. Acad Emerg Med. 2018 Mar;25(3):261-266. doi: 10.1111/acem.13345. Epub 2017 Dec 9.
Association of Preprocedural Fasting With Outcomes of Emergency Department Sedation in Children
Bhatt M et al. Association of Preprocedural Fasting With Outcomes of Emergency Department Sedation in Children. JAMA Pediatr. 2018 Jul 1;172(7):678-685. doi: 10.1001/jamapediatrics.2018.0830.
Epidemiology/Biostatistics Resource Person: Dr. Frank Scheuermeyer
Sept. 18, 2018
A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest
Perkins et al. A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2018 Aug 23;379(8):711-721. doi: 10.1056/NEJMoa1806842. Epub 2018 Jul 18.
Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis
Kuppermann et al. Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis. N Engl J Med. 2018 Jun 14;378(24):2275-2287. doi: 10.1056/NEJMoa1716816.
Epidemiology/Biostatistics Resource Person: Dr. Brian Grunau and Dr. David Barbic
June 19, 2018
A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis
Franklin D, Babl FE, Schlapbach LJ, Oakley E, Craig S, Neutze J, Furyk J, Fraser JF, Jones M, Whitty JA, Dalziel SR, Schibler A. A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis. N Engl J Med. 2018 Mar 22;378(12):1121-1131. doi: 10.1056/NEJMoa1714855.
Prediction and risk stratification of survival in accidental hypothermia requiring extracorporeal life support: An individual patient data metaanalysis
Saczkowski RS, Brown DJA, Abu-Laban RB, Fradet G, Schulze CJ, Kuzak ND. Prediction and risk stratification of survival in accidental hypothermia requiring extracorporeal life support: An individual patient data meta-analysis. Resuscitation. 2018 Mar 23;127:51-57. doi: 10.1016/j.resuscitation.2018.03.028. [Epub ahead of print]
Epidemiology/Biostatistics Resource Person: Dr. Frank Sheuermeyer
May 15, 2018
Balanced Crystalloids versus Saline in Noncritically Ill Adults
Self WH, Semler MW, Wanderer JP, Wang L, Byrne DW, Collins SP, Slovis CM, Lindsell CJ, Ehrenfeld JM, Siew ED, Shaw AD, Bernard GR, Rice TW; SALT-ED Investigators. Balanced Crystalloids versus Saline in Noncritically Ill Adults. N Engl J Med. 2018 Mar 1;378(9):819-828. doi: 10.1056/NEJMoa1711586. Epub 2018 Feb 27.
Syncope Prognosis Based on Emergency Department Diagnosis: A Prospective Cohort Study
Toarta C, Mukarram M, Arcot K, Kim SM, Gaudet S, Sivilotti MLA, Rowe BH, Thiruganasambandamoorthy V. Syncope Prognosis Based on Emergency Department Diagnosis: A Prospective Cohort Study. Acad Emerg Med. 2018 Apr;25(4):388-396. doi: 10.1111/acem.13346. Epub 2018 Jan 11.
Epidemiology/Biostatistics Resource Person: Dr. Jeff Brubacher
Apr. 17, 2018
Emergency Department use of Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation: A Randomized Controlled Trial (The ENDAO Trial)
Caputo N, Azan B, Domingues R, Donner L, Fenig M, Fields D, Fraser R, Hosford K, Iuorio R, Kanter M, McCarty M, Parry T, Raja A, Ryan M, Williams B, Sharma H, Singer D, Shields C, Scott S, West JR; Lincoln Airway Group. Emergency Department use of Apneic Oxygenation Versus Usual Care During Rapid SequenceIntubation: A Randomized Controlled Trial (The ENDAO Trial). Acad Emerg Med. 2017 Nov;24(11):1387-1394. doi: 10.1111/acem.13274. Epub 2017 Sep 23.
Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial
Freund Y, Cachanado M, Aubry A, Orsini C, Raynal PA, Féral-Pierssens AL, Charpentier S, Dumas F, Baarir N, Truchot J, Desmettre T, Tazarourte K, Beaune S, Leleu A, Khellaf M, Wargon M, Bloom B, Rousseau A, Simon T, Riou B1; PROPER Investigator Group. Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic EventsAmong Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial. JAMA. 2018 Feb 13;319(6):559-566. doi: 10.1001/jama.2017.21904.
Is the Pelvic Examination Still Crucial in Patients Presenting to the Emergency Department With Vaginal Bleeding or Abdominal Pain When an Intrauterine Pregnancy Is Identified on Ultrasonography? A Randomized Controlled Trial
Linden JA, Grimmnitz B, Hagopian L, Breaud AH, Langlois BK, Nelson KP, Hart LL, Feldman JA, Brown J, Reid M, Desormeau E, Mitchell PM. Is the Pelvic Examination Still Crucial in Patients Presenting to the Emergency DepartmentWith Vaginal Bleeding or Abdominal Pain When an Intrauterine Pregnancy Is Identified on Ultrasonography? A Randomized Controlled Trial. Ann Emerg Med. 2017 Dec;70(6):825-834. doi: 10.1016/j.annemergmed.2017.07.487. Epub 2017 Sep 19.
Epidemiology/Biostatistics Resource Person: Dr. Garth Hunte
Mar. 20, 2018
Effect of Bag-Mask Ventilation vs Endotracheal Intubation During Cardiopulmonary Resuscitation on Neurological Outcome After Out-of-Hospital Cardiorespiratory Arrest: A Randomized Clinical Trial
Jabre P et al. Effect of Bag-Mask Ventilation vs Endotracheal Intubation During Cardiopulmonary Resuscitation on Neurological Outcome After Out-of-Hospital Cardiorespiratory Arrest: A Randomized Clinical Trial. JAMA. 2018 Feb 27;319(8):779-787. doi: 10.1001/jama.2018.0156.
The Impact of a Soiled Airway on Intubation Success in the Emergency Department When Using the GlideScope or the Direct Laryngoscope
Sakles JC, Corn GJ, Hollinger P, Arcaris B, Patanwala AE, Mosier JM. The Impact of a Soiled Airway on Intubation Success in the Emergency Department When Using the GlideScope or the Direct Laryngoscope. Acad Emerg Med. 2017 May;24(5):628-636. doi: 10.1111/acem.13160. Epub 2017 Mar 17.
The Bougie and First-Pass Success in the Emergency Department
Driver B, Dodd K, Klein LR, Buckley R, Robinson A, McGill JW, Reardon RF, Prekker ME. The Bougie and First-Pass Success in the Emergency Department. Ann Emerg Med. 2017 Oct;70(4):473-478.e1. doi: 10.1016/j.annemergmed.2017.04.033.
Epidemiology/Biostatistics Resource Person: Dr. Riyad Abu-Laban
Feb. 20, 2018
British Columbia’s pay-for-performance experiment: part of the solution to reduce emergency department crowding?
Cheng AH, Sutherland JM. British Columbia’s pay-for-performance experiment: part of the solution to reduce emergency department crowding? Health Policy. 2013 Nov;113(1-2):86-92. doi: 10.1016/j.healthpol.2013.07.010.
The Effect of Pay for Performance in the Emergency Department on Patient Waiting Times and Quality of Care in Ontario, Canada: A Difference-in-Differences Analysis
Vermeulen MJ, Stukel TA, Boozary AS, Guttmann A, Schull MJ. The Effect of Pay for Performance in the Emergency Department on Patient Waiting Times and Quality of Care in Ontario, Canada: A Difference-in-Differences Analysis. Ann Emerg Med. 2016 Apr;67(4):496-505.e7. doi: 10.1016/j.annemergmed.2015.06.028.
Epidemiology/Biostatistics Resource Person: Dr. Les Vertesi
Jan. 16, 2018
No added value of the age-adjusted D-dimer cut-off to the YEARS algorithm in patients with suspected pulmonary embolism
van der Pol LM, et al. No added value of the age-adjusted D-dimer cut-off to the YEARS algorithm in patients with suspected pulmonary embolism. J Thromb Haemost. 2017 Dec;15(12):2317-2324. doi: 10.1111/jth.13852. Epub 2017 Oct 24.
Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery
Mazer CD et al, TRICS Investigators and Perioperative Anesthesia Clinical Trials Group. Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery. N Engl J Med. 2017 Nov 30;377(22):2133-2144. doi: 10.1056/NEJMoa1711818. Epub 2017 Nov 12.
Epidemiology/Biostatistics Resource Person: Dr. Rob Stenstrom
Dec. 19, 2017
Prospective validation of a clinical decision rule to identify patients presenting to the emergency department with chest pain who can safely be removed from cardiac monitoring
Syed S, Gatien M, Perry JJ, Chaudry H, Kim SM, Kwong K, Mukarram M, Thiruganasambandamoorthy V. Prospective validation of a clinical decision rule to identify patients presenting to the emergency department with chest pain who can safely be removed from cardiac monitoring. CMAJ. 2017 Jan 30;189(4):E139-E145. doi: 10.1503/cmaj.160742.
Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial
Chang AK, Bijur PE, Esses D, Barnaby DP, Baer J. Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial. JAMA. 2017 Nov 7;318(17):1661-1667. doi: 10.1001/jama.2017.16190.
Epidemiology/Biostatistics Resource Person: Dr. Jessica Moe
Nov. 21, 2017
Increased mortality in trauma patients who develop postintubation hypotension
Green RS, Butler MB, Erdogan M. Increased mortality in trauma patients who develop postintubation hypotension. J Trauma Acute Care Surg. 2017 Oct;83(4):569-574. doi: 10.1097/TA.0000000000001561.
Emergency department-initiated buprenorphine/naloxone treatment for opioid dependence: a randomized clinical trial
D’Onofrio G, O’Connor PG, Pantalon MV, Chawarski MC, Busch SH, Owens PH, Bernstein SL, Fiellin DA. Emergency department-initiated buprenorphine/naloxone treatment for opioid dependence: a randomized clinical trial. JAMA. 2015 Apr 28;313(16):1636-44. doi: 10.1001/jama.2015.3474.
Epidemiology/Biostatistics Resource Person: Dr. Corinne Hohl
Oct. 17, 2017
Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial
Nijssen EC, Rennenberg RJ, Nelemans PJ, Essers BA, Janssen MM, Vermeeren MA, Ommen VV, Wildberger JE. Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial. Lancet. 2017 Apr 1;389(10076):1312-1322. doi: 10.1016/S0140-6736(17)30057-0. Epub 2017 Feb 21.
Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure
Matsue Y, Damman K, Voors AA, Kagiyama N, Yamaguchi T, Kuroda S, Okumura T, Kida K, Mizuno A, Oishi S, Inuzuka Y, Akiyama E, Matsukawa R, Kato K, Suzuki S, Naruke T, Yoshioka K, Miyoshi T, Baba Y, Yamamoto M, Murai K, Mizutani K, Yoshida K, Kitai T Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure. J Am Coll Cardiol. 2017 Jun 27;69(25):3042-3051. doi: 10.1016/j.jacc.2017.04.042.
Epidemiology/Biostatistics Resource Person: Dr. Frank Scheuermeyer
Sept. 7, 2017
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial
Motov S, Yasavolian M, Likourezos A, Pushkar I, Hossain R, Drapkin J, Cohen V, Filk N, Smith A, Huang F2, Rockoff B, Homel P, Fromm C. Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2017 Aug;70(2):177-184. doi: 10.1016/j.annemergmed.2016.10.014. Epub 2016 Dec 16.
Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain
Ahern TL, Herring AA, Miller S, Frazee BW. Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain. Pain Med. 2015 Jul;16(7):1402-9. doi: 10.1111/pme.12705. Epub 2015 Feb 3.
Epidemiology/Biostatistics Resource Person: Dr. Riyad Abu-Laban
June 1, 2017
Hydrocortisone, Vitamin C and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After StudyMarik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2016 Dec 6. pii: S0012-3692(16)62564-3. doi: 10.1016/j.chest.2016.11.036. [Epub ahead of print]
Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial
Hayward GN, Hay AD, Moore MV, Jawad S, Williams N, Voysey M, Cook J, Allen J, Thompson M, Little P, Perera R, Wolstenholme J, Harman K, Heneghan C. Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial. JAMA. 2017 Apr 18;317(15):1535-1543. doi: 10.1001/jama.2017.3417.
Epidemiology/Biostatistics Resource Person: Dr. John Tallon
May 4, 2017
Cervical spine collar clearance in the obtunded adult blunt trauma patient: a systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma
Patel MB, Humble SS, Cullinane DC, Day MA, Jawa RS, Devin CJ, Delozier MS, Smith LM, Smith MA, Capella JM, Long AM, Cheng JS, Leath TC, Falck-Ytter Y, Haut ER, Como JJ. Cervical spine collar clearance in the obtunded adult blunt trauma patient: a systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2015 Feb;78(2):430-41. doi: 10.1097/TA.0000000000000503.
Defining the cervical spine clearance algorithm: A single-institution prospective study of more than 9,000 patients
Duane TM, Young AJ, Vanguri P, Wolfe LG, Katzen J, Han J, Mayglothling J, Whelan JF, Aboutanos MB, Ivatury RR, Malhotra AK. Defining the cervical spine clearance algorithm: A single-institution prospective study of more than 9,000 patients. J Trauma Acute Care Surg. 2016 Sep;81(3):541-7. doi: 10.1097/TA.0000000000001151.
Epidemiology/Biostatistics Resource Person: Dr. Jeff Brubacher
April 6, 2017
Major Adverse Events and Relationship to Nil per Os Status in Pediatric Sedation/Anesthesia Outside the Operating Room: A Report of the Pediatric Sedation Research Consortium
Beach ML, Cohen DM, Gallagher SM, Cravero JP. Major Adverse Events and Relationship to Nil per Os Status in Pediatric Sedation/Anesthesia Outside the Operating Room: A Report of the Pediatric Sedation Research Consortium. Anesthesiology. 2016 Jan;124(1):80-8. doi: 10.1097/ALN.0000000000000933.
Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival
Andersen LW, Granfeldt A, Callaway CW, Bradley SM, Soar J, Nolan JP, Kurth T, Donnino MW; American Heart Association’s Get With The Guidelines–Resuscitation Investigators. Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival. JAMA. 2017 Feb 7;317(5):494-506. doi: 10.1001/jama.2016.20165.
Epidemiology/Biostatistics Resource Person: Dr. Rob Stenstrom
March 2, 2017
Risk of Acute Kidney Injury After Intravenous Contrast Media Administration
Hinson JS, Ehmann MR, Fine DM, Fishman EK, Toerper MF, Rothman RE, Klein EY. Risk of Acute Kidney Injury After Intravenous Contrast Media Administration. Ann Emerg Med. 2017 Jan 19. pii: S0196-0644(16)31388-9. doi: 10.1016/j.annemergmed.2016.11.021. [Epub ahead of print]
Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage
Qureshi AI, Palesch YY, Barsan WG, Hanley DF, Hsu CY, Martin RL, Moy CS, Silbergleit R, Steiner T, Suarez JI, Toyoda K, Wang Y, Yamamoto H, Yoon BW; ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network. Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. N Engl J Med. 2016 Sep 15;375(11):1033-43. doi: 10.1056/NEJMoa1603460. Epub 2016 Jun 8.
Epidemiology/Biostatistics Resource Person: Dr. Devin Harris
Feb. 9, 2017
Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope
Thiruganasambandamoorthy V, Kwong K, Wells GA, Sivilotti ML, Mukarram M, Rowe BH, Lang E, Perry JJ, Sheldon R, Stiell IG, Taljaard M. Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope. CMAJ. 2016 Sep 6;188(12):E289-98. doi: 10.1503/cmaj.151469. Epub 2016 Jul 4
Effect of early supervised physiotherapy on recovery from acute ankle sprain: randomised controlled trial
Brison RJ, Day AG Pelland L, Pickett W, Johnson AP, Aiken A, Pichora DR, Brouwer B. Effect of early supervised physiotherapy on recovery from acute ankle sprain: randomised controlled trial. BMJ. 2016 Nov 16;355:i5650. doi: 10.1136/bmj.i5650.
Epidemiology/Biostatistics Resource Person: Dr. David Barbic
Jan 5, 2017
Oral Prednisolone in the Treatment of Acute Gout: A Pragmatic, Multicenter, Double-Blind, Randomized Trial
Rainer TH, Cheng CH, Janssens HJ, Man CY, Tam LS, Choi YF, Yau WH, Lee KH, Graham CA. Oral Prednisolone in the Treatment of Acute Gout: A Pragmatic, Multicenter, Double-Blind, Randomized Trial. Ann Intern Med. 2016 Apr 5;164(7):464-71. doi: 10.7326/M14-2070. Epub 2016 Feb 23.
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial
Beadle KL, Helbling AR, Love SL, April MD, Hunter CJ. Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2016 Jul;68(1):1-9.e1. doi: 10.1016/j.annemergmed.2015.09.031. Epub 2015 Dec 8.
Epidemiology/Biostatistics Resource Person: Dr. Riyad Abu-Laban
Dec 1, 2016
Radiograph-Negative Lateral Ankle Injuries in Children: Occult Growth Plate Fracture or Sprain?
Boutis K, Plint A, Stimec J, Miller E, Babyn P, Schuh S, Brison R, Lawton L, Narayanan UG. Radiograph-Negative Lateral Ankle Injuries in Children: Occult Growth Plate Fracture or Sprain? JAMA Pediatr. 2016 Jan;170(1):e154114. doi: 10.1001/jamapediatrics.2015.4114. Epub 2016 Jan 4.
Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope
Prandoni P, Lensing AW, Prins MH, Ciammaichella M, Perlati M, Mumoli N, Bucherini E, Visonà A, Bova C, Imberti D, Campostrini S, Barbar S; PESIT Investigators. Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope. N Engl J Med. 2016 Oct 20;375(16):1524-1531.
Epidemiology/Biostatistics Resource Person: Dr. Garth Hunte
Nov 3, 2016
Head-Elevated Patient Positioning Decreases Complications of Emergent Tracheal Intubation in the Ward and Intensive Care Unit
Khandelwal N, Khorsand S, Mitchell SH, Joffe AM. Head-Elevated Patient Positioning Decreases Complications of Emergent Tracheal Intubation in the Ward and Intensive Care Unit. Anesth Analg. 2016 Apr;122(4):1101-7. doi: 10.1213/ANE.0000000000001184.
Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke
Anderson CS, Robinson T, Lindley RI, Arima H, Lavados PM, Lee TH, Broderick JP, Chen X, Chen G, Sharma VK, Kim JS, Thang NH, Cao Y, Parsons MW, Levi C, Huang Y, Olavarría VV, Demchuk AM, Bath PM, Donnan GA, Martins S, Pontes-Neto OM, Silva F, Ricci S, Roffe C, Pandian J, Billot L, Woodward M, Li Q, Wang X, Wang J, Chalmers J; ENCHANTED Investigators and Coordinators. Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke. N Engl J Med. 2016 Jun 16;374(24):2313-23. doi: 10.1056/NEJMoa1515510. Epub 2016 May 10.
Epidemiology/Biostatistics Resource Person: n/a
Oct 6, 2016
Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial
Freedman SB, Willan AR, Boutis K, Schuh S. Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial. JAMA. 2016 May 10;315(18):1966-74. doi: 10.1001/jama.2016.5352.
Propofol or Ketofol for Procedural Sedation and Analgesia in Emergency Medicine-The POKER Study: A Randomized Double-Blind Clinical Trial
Ferguson I, Bell A, Treston G, New L, Ding M, Holdgate A. Propofol or Ketofol for Procedural Sedation and Analgesia in Emergency Medicine-The POKER Study: A Randomized Double-Blind Clinical Trial. Ann Emerg Med. 2016 Jul 22. pii: S0196-0644(16)30204-9. doi: 10.1016/j.annemergmed.2016.05.024. [Epub ahead of print]
Epidemiology/Biostatistics Resource Person: Dr. Corinne Hohl
Sept 8, 2016
Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study
Ortiz M, Martín A, Arribas F, Coll-Vinent B, Del Arco C, Peinado R, Almendral J; PROCAMIO Study Investigators. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. Eur Heart J. 2016 Jun 28. pii: ehw230. [Epub ahead of print]
High-Dose magnesium sulfate infusion for severe asthma in the emergency department: efficacy study
Irazuzta JE, Paredes F, Pavlicich V, Domínguez SL. High-dose magnesium sulfate infusion for severe asthma in the emergency department: efficacy study. Pediatr Crit Care Med. 2016 Feb;17(2):e29-33.
Epidemiology/Biostatistics Resource Person: Dr. Frank Scheuermeyer
June 14, 2016
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW, Christenson J, Egan D, Ornato JP, Weisfeldt ML, Stiell IG, Idris AH, Aufderheide TP, Dunford JV, Colella MR, Vilke GM, Brienza AM, Desvigne-Nickens P, Gray PC, Gray R, Seals N, Straight R, Dorian P; Resuscitation Outcomes Consortium Investigators. Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2016 May 5;374(18):1711-22. doi: 10.1056/NEJMoa1514204. Epub 2016 Apr 4.
Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess
Talan DA, Mower WR, Krishnadasan A, Abrahamian FM, Lovecchio F, Karras DJ, Steele MT, Rothman RE, Hoagland R, Moran GJ. Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess. N Engl J Med. 2016 Mar 3;374(9):823-32. doi: 10.1056/NEJMoa1507476.
Delivering safe and effective analgesia for management of renal colic in the emergency department: a double-blind, multigroup, randomised controlled trial
Pathan SA, Mitra B, Straney LD, Afzal MS, Anjum S, Shukla D, Morley K, Al Hilli SA, Al Rumaihi K, Thomas SH, Cameron PA. Delivering safe and effective analgesia for management of renal colic in the emergency department: a double-blind, multigroup, randomised controlled trial. Lancet. 2016 May 14;387(10032):1999-2007. doi: 10.1016/S0140-6736(16)00652-8. Epub 2016 Mar 16.
Epidemiology/Biostatistics Resource Person: Dr. Garth Hunte
April 7, 2016
A clinical decision instrument for 30-Day death after an emergency department visit for atrial fibrillation: the atrial fibrillation in the emergency room (AFTER) study
Atzema CL et al. A Clinical Decision Instrument for 30-Day Death After an Emergency Department Visit for Atrial Fibrillation: The Atrial Fibrillation in the Emergency Room (AFTER) Study. Ann Emerg Med. 2015 Dec; 66(6): 656-668
Intravascular complications of central venous catheterization by insertion site
Parienti JJ, Mongardon N, Mégarbane B, Mira JP, Kalfon P, Gros A, Marqué S, Thuong M, Pottier V, Ramakers M, Savary B, Seguin A, Valette X, Terzi N, Sauneuf B, Cattoir V, Mermel LA, du Cheyron D; 3SITES Study Group. Intravascular Complications of Central Venous Catheterization by Insertion Site. N Engl J Med. 2015 Sep 24;373(13):1220-9.
Epidemiology/Biostatistics Resource Person: Dr. Rob Stenstrom
March 3, 2016
A randomized controlled trial of intravenous haloperidol vs. intravenous metoclopramide for acute migraine therapy in the emergency department
Gaffigan ME, Bruner DI, Wason C, Pritchard A, Frumkin K. A randomized controlled trial of intravenous haloperidol vs. intravenous metoclopramide for acute migraine therapy in the emergency department. J Emerg Med. 2015 Sep;49(3):326-34.
The validity of abdominal examination in blunt trauma patients with distracting injuries
Rostas J, Cason B, Simmons J, Frotan MA, Brevard SB, Gonzalez RP. The validity of abdominal examination in blunt trauma patients with distracting injuries. J Trauma Acute Care Surg. 2015 Jun;78(6):1095-100 ; discussion 1100 – 1.
Epidemiology/Biostatistics Resource Person: Dr. Les Vertesi
Feb 4, 2016
CT within 6 hours of headache onset to rule out subarachnoid hemorrhage in nonacademic hospitals
Blok KM, Rinkel GJ, Majoie CB, Hendrikse J, Braaksma M, Tijssen CC, Wong YY, Hofmeijer J, Extercatte J, Kerklaan B, Schreuder TH, ten Holter S, Verheul F, Harlaar L, Pruissen DM, Kwa VI, Brouwers PJ, Remmers MJ, Schonewille WJ, Kruyt ND, Vergouwen MD. CT within 6 hours of headache onset to rule out subarachnoid hemorrhage in nonacademic hospitals. Neurology. 2015 May 12;84(19):1927-32. doi: 10.1212/WNL.0000000000001562. Epub 2015 Apr 10.
Does a single dose of intravenous dexamethasone reduce symptoms in emergency department patients with low back pain and radiculopathy (SEBRA)? A double-blind randomised controlled trial
Balakrishnamoorthy R, Horgan I, Perez S, Steele MC, Keijzers GB. Does a single dose of intravenous dexamethasone reduce Symptoms in Emergency department patients with low Back pain and RAdiculopathy (SEBRA)? A double-blind randomised controlled trial. Emerg Med J. 2015 Jul;32(7):525-30. doi: 10.1136/emermed-2013-203490. Epub 2014 Aug 13.
Epidemiology/Biostatistics Resource Person: Dr. David Barbic
Jan 7, 2016
Trial of continuous or interrupted chest compressions during CPR
Nichol G, Leroux B, Wang H, Callaway CW, Sopko G, Weisfeldt M, Stiell I, Morrison LJ, Aufderheide TP, Cheskes S, Christenson J, Kudenchuk P, Vaillancourt C, Rea TD, Idris AH, Colella R, Isaacs M, Straight R, Stephens S, Richardson J, Condle J, Schmicker RH, Egan D, May S, Ornato JP; ROC Investigators. Trial of continuous or interrupted chest compressions during CPR. N Engl J Med. 2015 Dec 3;373(23):2203-14. doi: 10.1056/NEJMoa1509139. Epub 2015 Nov 9.
Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay
Reichlin T, et al. Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay. CMAJ. 2015 May. 187(8). doi: 10.1503/cmaj.141349
Epidemiology/Biostatistics Resource Person: Dr. Riyad Abu-Laban
Dec 3, 2015
Naproxen With cyclobenzaprine, oxycodone/acetaminophen, or placebo for treating acute low back pain: a randomized clinical trial
Friedman BW, Dym AA, Davitt M, Holden L, Solorzano C, Esses D, Bijur PE, Gallagher EJ. Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA. 2015 Oct 20;314(15):1572-80. doi: 10.1001/jama.2015.13043
FAST ultrasound examination as a predictor of outcomes after resuscitative thoracotomy: a prospective evaluation
Inaba, Kenji, Konstantinos Chouliaras, Scott Zakaluzny, Stuart Swadron, Thomas Mailhot, Dina Seif, Pedro Teixeira, et al. 2015. FAST ultrasound examination as a predictor of outcomes after resuscitative thoracotomy: a prospective evaluation. Annals of surgery, no. 3. doi:10.1097/SLA.0000000000001421.
Epidemiology/Biostatistics Resource Person: Dr. Devin Harris
Nov 5, 2015
Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial
Pickard R, Starr K, MacLennan G, Lam T, Thomas R, Burr J, McPherson G, McDonald A, Anson K, N’Dow J, Burgess N, Clark T, Kilonzo M, Gillies K, Shearer K, Boachie C, Cameron S, Norrie J, McClinton S. Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial. Lancet. 2015 Jul 25;386(9991):341-9. doi: 10.1016/S0140-6736(15)60933-3. Epub 2015 May 18.
Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial
Appelboam A, Reuben A, Mann C, Gagg J, Ewings P, Barton A, Lobban T, Dayer M, Vickery J, Benger J; REVERT trial collaborators. Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial. Lancet. 2015 Aug 24. pii: S0140-6736(15)61485-4. doi: 10.1016/S0140-6736(15)61485-4. [Epub ahead of print]
Epidemiology/Biostatistics Resource Person: Dr. Iain MacPhail
Oct 1, 2015
Adjunct prednisone therapy for patients with community acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial
Blum, Claudine Angela et al. Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet 2015 Apr 19;385(9977):1511-8. Epub 2015 Jan 19.
Diltiazem vs. metoprolol in the management of atrial fibrillation or flutter with rapid ventricular rate in the emergency department
Fromm C, Suau SJ, Cohen V, Likourezos A, Jellinek-Cohen S, Rose J, Marshall J. Diltiazem vs. Metoprolol in the Management of Atrial Fibrillation or Flutter with Rapid Ventricular Rate in the Emergency Department. J Emerg Med. 2015 Aug;49(2):175-82. doi: 10.1016/j.jemermed.2015.01.014. Epub 2015 Apr 22.
Epidemiology/Biostatistics Resource Person: Dr. Corinne Hohl
Sept 10, 2015
Randomized assessment of rapid endovascular treatment of ischemic stroke
Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA, Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Williams D, Bang OY, Baxter BW, Burns PA, Choe H, Heo JH, Holmstedt CA, Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn SI, Swartz RH, Barber PA, Coutts SB, Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill MD; ESCAPE Trial Investigators. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015 Mar 12;372(11):1019-30. Epub 2015 Feb 11.
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure
Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R; FLORALI Study Group; REVA Network. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015 Jun 4;372(23):2185-96. Epub 2015 May 17.
Epidemiology/Biostatistics Resource Person: Dr. Frank Scheuermeyer
May 7, 2015
Emergency department corticosteroid use for allergy or anaphylaxis is not associate with decreased relapses
Grunau BE, Wiens MO, Rowe BH, McKay R, Li J, Yi TW, Stenstrom R, Schellenberg RR, Grafstein E, Scheuermeyer FX. Emergency department corticosteroid use for allergy or anaphylaxis is not associated with cecreased relapses. Ann Emerg Med. 2015 Mar 25. pii: S0196-0644(15)00190-0. doi: 10.1016/j.annemergmed.2015.03.003. [Epub ahead of print]
Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit:
a randomized trial
Parshuram CS, Amaral AC, Ferguson ND, Baker GR, Etchells EE, Flintoft V, Granton J, Lingard L, Kirpalani H, Mehta S, Moldofsky H, Scales DC, Stewart TE, Willan AR, Friedrich JO; Canadian Critical Care Trials Group. Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit: a randomized trial. CMAJ. 2015 Mar 17;187(5):321-9. doi: 10.1503/cmaj.140752. Epub 2015 Feb 9.
Background reading: Resident duty-hour reform: moving beyond “change for change’s sake”
Epidemiology/Biostatistics Resource Person: Dr. Jeff Brubacher
April 2, 2015
Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma – the PROPPR randomized clinical trial
Holcomb JB et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma – the PROPPR randomized clinical trial. JAMA. 2015;313(5):471-482. doi:10.1001/jama.2015.12.
View Article Appraisal + Addendum
Treatment of pulmonary embolism with rivaroxaban: outcomes by simplified pulmonary embolism severity index score from a post hoc analysis of the EINSTEIN PE study
Fermann GJ, Erkens PM, Prins MH, Wells PS, Pap ÁF, Lensing AW. Treatment of pulmonary embolism with rivaroxaban: outcomes by simplified pulmonary embolism severity index score from a post hoc analysis of the EINSTEIN PE study. Acad Emerg Med. 2015 Mar;22(3):299-307. doi: 10.1111/acem.12615. Epub 2015 Feb 25.
Epidemiology/Biostatistics Resource Person: Dr. Riyad Abu-Laban
March 5, 2015
A comparison of acute treatment regimens for migraine in the emergency department
Bachur RG, Monuteaux MC, Neuman M. A comparison of acute treatment regimens for migraine in the emergency department. Pediatrics. 2015 Feb;135(2):232-8.
Nebulized fentanyl vs intravenous morphine for ED patients with acute limb pain: a randomized clinical trial
Farahmand S, Shiralizadeh S, Talebian MT, Bagheri-Hariri S, Arbab M, Basirghafouri H, Saeedi M, Sedaghat M, Mirzababai H. Nebulized fentanyl vs intravenous morphine for ED patients with acute limb pain: a randomized clinical trial. Am J Emerg Med. 2014 Sep;32(9):1011-5.
Epidemiology/Biostatistics Resource Person: Dr. John Tallon
February 12, 2015
Traumatic lacerations: what are the risks for infection and has the ‘golden period’ of laceration care disappeared?
Quinn JV1, Polevoi SK, Kohn MA. Traumatic lacerations: what are the risks for infection and has the ‘golden period’ of laceration care disappeared? Emerg Med J. 2014 Feb;31(2):96-100. Epub 2013 Jan 12.
Ultrasonography versus computed tomography for suspected nephrolithiasis
Smith-Bindman R, Aubin C, Bailitz J, Bengiamin R, Camargo C, et al. Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis. New England Journal of Medicine. 2014 Sep 18; 371:1100-1110.
Epidemiology/Biostatistics Resource Person: Dr. Rob Stenstrom
January 8, 2015
Outcomes after out-of-hospital cardiac arrest treated by basic vs advanced life support
Sanghavi P, Jena AB, Newhouse JP, Zaslavsky AM. Outcomes After Out-of-Hospital Cardiac Arrest Treated by Basic vs Advanced Life Support. JAMA Intern Med. 2014 Nov 24. DOI: 10.1001/jamainternmed.2014.5420. [Epub ahead of print]
Delayed sequence intubation: a prospective observational study
Weingart SD, Trueger NS, Wong N, Scofi J, Singh N, Rudolph SS. Delayed Sequence Intubation: A Prospective Observational Study. Ann Emerg Med. 2014 Oct 23. pii: S0196-0644(14)01365-1. DOI: 10.1016/j.annemergmed.2014.09.025. [Epub ahead of print]
January Epidemiology/Biostatistics Resource Person: Corinne Hohl
December 5, 2014
Operative versus nonoperative treatment in the management of midshaft clavicular fractures: a meta-analysis of randomized controlled trials
Xu J, Xu L, Xu W, Gu Y, Xu J. Operative versus nonoperative treatment in the management of midshaft clavicular fractures: a meta-analysis of randomized controlled trials. J Shoulder Elbow Surg. 2014 Feb;23(2):173-81. doi: 10.1016/j.jse.2013.06.025. Epub 2013 Oct 12.
Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis
Chatterjee S, Chakraborty A, Weinberg I, Kadakia M, Wilensky RL, Sardar P, Kumbhani DJ, Mukherjee D, Jaff MR, Giri J. Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis. JAMA. 2014 Jun 18;311(23):2414-21. doi: 10.1001/jama.2014.5990
December Epidemiology/Biostatistics Resource Person: Iain MacPhail
November 6, 2014
Lower versus higher hemoglobin threshold for transfusion in septic shock
Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, Johansson PI, Aneman A, Vang ML, Winding R, Nebrich L, Nibro HL, Rasmussen BS, Lauridsen JR, Nielsen JS, Oldner A, Pettilä V, Cronhjort MB, Andersen LH, Pedersen UG, Reiter N, Wiis J, White JO, Russell L, Thornberg KJ, Hjortrup PB, Müller RG, Møller MH, Steensen M, Tjäder I, Kilsand K, Odeberg-Wernerman S, Sjøbø B, Bundgaard H, Thyø MA, Lodahl D, Mærkedahl R, Albeck C, Illum D, Kruse M, Winkel P, Perner A; TRISS Trial Group; Scandinavian Critical Care Trials Group. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med. 2014 Oct 9;371(15):1381-91. doi: 10.1056/NEJMoa1406617
Ambulatory management of large spontaneous pneumothorax with
pigtail catheters
Voisin F, Sohier L, Rochas Y, Kerjouan M, Ricordel C, Belleguic C, Desrues B, Jouneau S. Ambulatory management of large spontaneous pneumothorax with pigtail catheters. Ann Emerg Med. 2014 Sep;64(3):222-8. doi: 10.1016/j.annemergmed.2013.12.017
November Epidemiology/Biostatistics Resource Person: Les Vertesi
October 2, 2014
Antiemetic use for nausea and vomiting in adult emergency department patients: randomized controlled trial comparing ondansetron, metoclopramide, and placebo
Egerton-Warburton D, Meek R, Mee MJ, Braitberg G. Antiemetic Use for Nausea and Vomiting in Adult Emergency Department Patients: Randomized Controlled Trial Comparing Ondansetron, Metoclopramide, and Placebo. Ann Emerg Med. 2014 May 9. pii: S0196-0644(14)00223-6. DOI: 10.1016/j.annemergmed.2014.03.017
Comparison of PECARN, CATCH, and CHALICE rules for children with minor head injury: a prospective cohort study
Easter JS, Bakes K, Dhaliwal J, Miller M, Caruso E, Haukoos JS. Comparison of PECARN, CATCH, and CHALICE rules for children with minor head injury: a prospective cohort study. Ann Emerg Med. 2014 Aug;64(2):145-52, 152.e1-5. DOI: 10.1016/j.annemergmed.2014.01.030. Epub 2014 Mar 11.
October Epidemiology/Biostatistics Resource Person: David Barbic
September 4, 2014
Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial
He J, Zhang Y, Xu T, Zhao Q, Wang D, Chen CS, Tong W, Liu C, Xu T, Ju Z, Peng Y, Peng H, Li Q, Geng D, Zhang J, Li D, Zhang F, Guo L, Sun Y, Wang X, Cui Y, Li Y, Ma D, Yang G, Gao Y, Yuan X, Bazzano LA, Chen J; CATIS Investigators. Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke the CATIS randomized clinical trial. JAMA. 2014 Feb 5;311(5):479-89. DOI: 10.1001/jama.2013.282543
A case-controlled comparison of thrombolysis outcomes between wake-up and known time of onset ischemic stroke patients
Manawadu D, Bodla S, Jarosz J, Keep J, Kalra L. A case-controlled comparison of thrombolysis outcomes between wake-up and known time of onset ischemic stroke patientStroke. 2013 Aug;44(8):2226-31. DOI: 10.1161/STROKEAHA.111.000757
September Epidemiology/Biostatistics Resource Person: Riyad Abu-Laban
June 5, 2014
Derivation and validation of a clinical prediction rule for uncomplicated ureteral stone—the STONE score: retrospective and prospective observational cohort studies
Moore CL, Bomann S, Daniels B, Luty S, Molinaro A, Singh D, Gross CP. Derivation and validation of a clinical prediction rule for uncomplicated ureteral stone—the STONE score: retrospective and prospective observational cohort studies. BMJ. 2014 March;348:g2191.
Incidence of clinically important biphasic reactions in emergency department patients with allergic reactions or anaphylaxis
Grunau BE, Li J, Yi TW, Stenstrom R, Grafstein E, Wiens MO, Schellenberg RR, Scheuermeyer FX. Incidence of clinically important biphasic reactions in emergency department patients with allergic reactions or anaphylaxis. Ann Emerg Med. 2014 Jun;63(6):736-744.e2. Epub 2013 Nov 13.
June Epidemiology/Biostatistics Resource Person: Garth Hunte
May 1, 2014
An ED scribe program is able to improve throughput time and patient satisfaction
Bastani A, Shaqiri B, Palomba K, Bananno D, Anderson W. An ED scribe program is able to improve throughput time and patient satisfaction. Am J Emerg Med. 2014 May;32(5):399-402. Epub 2014 Mar 15
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Topical Tetracaine Used for 24 Hours Is Safe and Rated Highly Effective by Patients for the Treatment of Pain Caused by Corneal Abrasions: A Double-blind, Randomized Clinical Trial
Waldman N1, Densie IK, Herbison P. Topical Tetracaine Used for 24 Hours Is Safe and Rated Highly Effective by Patients for the Treatment of Pain Caused by Corneal Abrasions: A Double-blind, Randomized Clinical Trial. Acad Emerg Med. 2014 Apr;21(4):374-382.
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May Epidemiology/Biostatistics Resource Person: Frank Scheuermeyer
April 3, 2014
Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study
Righini M, Van Es J, Den Exter PL, et al. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. JAMA. 2014;311(11):1117-1124. doi:10.1001/jama.2014.2135
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A randomized trial of protocol-based care for early septic shock
The ProCESS Investigators. A Randomized Trial of Protocol-Based Care for Early Septic Shock. N Engl J Med. 2014 Mar 18. [Epub ahead of print]. DOI: 10.1056/NEJMoa1401602
April Epidemiology/Biostatistics Resource Person: Riyad Abu-Laban
March 6, 2014
Randomized clinical trial of efficacy and safety of a single 2-mg intravenous dose of hydromorphone versus usual care in the management of acute pain
Chang AK et al. Randomized Clinical Trial of Efficacy and Safety of a Single 2-mg Intravenous Dose of Hydromorphone Versus Usual Care in the Management of Acute Pain. Acad Emerg Med. 2013; 20, 185–192.
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Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage
Anderson et al. Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage. NEJM. 2014; 368(25): 2355-2365.
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March Epidemiology/Biostatistics Resource Person: John Tallon
February 6, 2014
Effect of cognitive activity level on duration of post-concussion symptoms
Brown NJ et al. Effect of Cognitive Activity Level on Duration of Post- Concussion Symptoms. Pediatrics. 2014; 133(2): 1-6.
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Nishijima DK et al. Immediate and delayed traumatic intracranial hemorrhage in patients with head trauma and preinjury warfarin or clopidogrel use. Ann Emerg Med. 2012 Jun;59(6):460-8. Cited in: PubMed; PMID 22626015.
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February Epidemiology/Biostatistics Resource Person: Ka Wai Cheung