Reviewed Articles

May 4, 2017

Cervical spine collar clearance in the obtunded adult blunt trauma patient: a systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma
Patel MB, Humble SS, Cullinane DC, Day MA, Jawa RS, Devin CJ, Delozier MS, Smith LM, Smith MA, Capella JM, Long AM, Cheng JS, Leath TC, Falck-Ytter Y, Haut ER, Como JJ. Cervical spine collar clearance in the obtunded adult blunt trauma patient: a systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2015 Feb;78(2):430-41. doi: 10.1097/TA.0000000000000503.

Reviewed Articles View Article Appraisal

 

Defining the cervical spine clearance algorithm: A single-institution prospective study of more than 9,000 patients
Duane TM, Young AJ, Vanguri P, Wolfe LG, Katzen J, Han J, Mayglothling J, Whelan JF, Aboutanos MB, Ivatury RR, Malhotra AK. Defining the cervical spine clearance algorithm: A single-institution prospective study of more than 9,000 patients. J Trauma Acute Care Surg. 2016 Sep;81(3):541-7. doi: 10.1097/TA.0000000000001151.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr.Jeff Brubacher


April 6, 2017

Major Adverse Events and Relationship to Nil per Os Status in Pediatric Sedation/Anesthesia Outside the Operating Room: A Report of the Pediatric Sedation Research Consortium
Beach ML, Cohen DM, Gallagher SM, Cravero JP. Major Adverse Events and Relationship to Nil per Os Status in Pediatric Sedation/Anesthesia Outside the Operating Room: A Report of the Pediatric Sedation Research Consortium. Anesthesiology. 2016 Jan;124(1):80-8. doi: 10.1097/ALN.0000000000000933.

Reviewed Articles View Article Appraisal

 

Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival
Andersen LW, Granfeldt A, Callaway CW, Bradley SM, Soar J, Nolan JP, Kurth T, Donnino MW; American Heart Association’s Get With The Guidelines–Resuscitation Investigators. Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival. JAMA. 2017 Feb 7;317(5):494-506. doi: 10.1001/jama.2016.20165.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Rob Stenstrom


March 2, 2017

Risk of Acute Kidney Injury After Intravenous Contrast Media Administration
Hinson JS, Ehmann MR, Fine DM, Fishman EK, Toerper MF, Rothman RE, Klein EY. Risk of Acute Kidney Injury After Intravenous Contrast Media Administration. Ann Emerg Med. 2017 Jan 19. pii: S0196-0644(16)31388-9. doi: 10.1016/j.annemergmed.2016.11.021. [Epub ahead of print]

Reviewed Articles View Article Appraisal

 

Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage
Qureshi AI, Palesch YY, Barsan WG, Hanley DF, Hsu CY, Martin RL, Moy CS, Silbergleit R, Steiner T, Suarez JI, Toyoda K, Wang Y, Yamamoto H, Yoon BW; ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network. Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. N Engl J Med. 2016 Sep 15;375(11):1033-43. doi: 10.1056/NEJMoa1603460. Epub 2016 Jun 8.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Devin Harris


 

Feb. 9, 2017

Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope
Thiruganasambandamoorthy V, Kwong K, Wells GA, Sivilotti ML, Mukarram M, Rowe BH, Lang E, Perry JJ, Sheldon R, Stiell IG, Taljaard M. Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope. CMAJ. 2016 Sep 6;188(12):E289-98. doi: 10.1503/cmaj.151469. Epub 2016 Jul 4

Reviewed Articles View Article Appraisal

 

Effect of early supervised physiotherapy on recovery from acute ankle sprain: randomised controlled trial
Brison RJ, Day AG Pelland L, Pickett W, Johnson AP, Aiken A, Pichora DR, Brouwer B. Effect of early supervised physiotherapy on recovery from acute ankle sprain: randomised controlled trial. BMJ. 2016 Nov 16;355:i5650. doi: 10.1136/bmj.i5650.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. David Barbic


Jan 5, 2017

Oral Prednisolone in the Treatment of Acute Gout: A Pragmatic, Multicenter, Double-Blind, Randomized Trial
Rainer TH, Cheng CH, Janssens HJ, Man CY, Tam LS, Choi YF, Yau WH, Lee KH, Graham CA. Oral Prednisolone in the Treatment of Acute Gout: A Pragmatic, Multicenter, Double-Blind, Randomized Trial. Ann Intern Med. 2016 Apr 5;164(7):464-71. doi: 10.7326/M14-2070. Epub 2016 Feb 23.

Reviewed Articles View Article Appraisal

 

Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial
Beadle KL, Helbling AR, Love SL, April MD, Hunter CJ. Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2016 Jul;68(1):1-9.e1. doi: 10.1016/j.annemergmed.2015.09.031. Epub 2015 Dec 8.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Riyad Abu-Laban


Dec 1, 2016

Radiograph-Negative Lateral Ankle Injuries in Children: Occult Growth Plate Fracture or Sprain?
Boutis K, Plint A, Stimec J, Miller E, Babyn P, Schuh S, Brison R, Lawton L, Narayanan UG. Radiograph-Negative Lateral Ankle Injuries in Children: Occult Growth Plate Fracture or Sprain? JAMA Pediatr. 2016 Jan;170(1):e154114. doi: 10.1001/jamapediatrics.2015.4114. Epub 2016 Jan 4.

Reviewed Articles View Article Appraisal

 

Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope
Prandoni P, Lensing AW, Prins MH, Ciammaichella M, Perlati M, Mumoli N, Bucherini E, Visonà A, Bova C, Imberti D, Campostrini S, Barbar S; PESIT Investigators. Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope. N Engl J Med. 2016 Oct 20;375(16):1524-1531.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Garth Hunte


Nov 3, 2016

Head-Elevated Patient Positioning Decreases Complications of Emergent Tracheal Intubation in the Ward and Intensive Care Unit
Khandelwal N, Khorsand S, Mitchell SH, Joffe AM. Head-Elevated Patient Positioning Decreases Complications of Emergent Tracheal Intubation in the Ward and Intensive Care Unit. Anesth Analg. 2016 Apr;122(4):1101-7. doi: 10.1213/ANE.0000000000001184.

Reviewed Articles View Article Appraisal

 

Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke
Anderson CS, Robinson T, Lindley RI, Arima H, Lavados PM, Lee TH, Broderick JP, Chen X, Chen G, Sharma VK, Kim JS, Thang NH, Cao Y, Parsons MW, Levi C, Huang Y, Olavarría VV, Demchuk AM, Bath PM, Donnan GA, Martins S, Pontes-Neto OM, Silva F, Ricci S, Roffe C, Pandian J, Billot L, Woodward M, Li Q, Wang X, Wang J, Chalmers J; ENCHANTED Investigators and Coordinators. Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke. N Engl J Med. 2016 Jun 16;374(24):2313-23. doi: 10.1056/NEJMoa1515510. Epub 2016 May 10.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: n/a


Oct 6, 2016

Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial 
Freedman SB, Willan AR, Boutis K, Schuh S. Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial. JAMA. 2016 May 10;315(18):1966-74. doi: 10.1001/jama.2016.5352.

Reviewed Articles View Article Appraisal

 

Propofol or Ketofol for Procedural Sedation and Analgesia in Emergency Medicine-The POKER Study: A Randomized Double-Blind Clinical Trial
Ferguson I, Bell A, Treston G, New L, Ding M, Holdgate A. Propofol or Ketofol for Procedural Sedation and Analgesia in Emergency Medicine-The POKER Study: A Randomized Double-Blind Clinical Trial. Ann Emerg Med. 2016 Jul 22. pii: S0196-0644(16)30204-9. doi: 10.1016/j.annemergmed.2016.05.024. [Epub ahead of print]

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Corinne Hohl


Sept 8, 2016

Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study
Ortiz M, Martín A, Arribas F, Coll-Vinent B, Del Arco C, Peinado R, Almendral J; PROCAMIO Study Investigators. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. Eur Heart J. 2016 Jun 28. pii: ehw230. [Epub ahead of print]

Reviewed Articles View Article Appraisal

 

High-Dose magnesium sulfate infusion for severe asthma in the emergency department: efficacy study
Irazuzta JE, Paredes F, Pavlicich V, Domínguez SL. High-dose magnesium sulfate infusion for severe asthma in the emergency department: efficacy study. Pediatr Crit Care Med. 2016 Feb;17(2):e29-33.

Reviewed article: Sept. 8, 2016 High Dose Magnesium Sulfate for Severe Asthma in the ED View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Frank Scheuermeyer


June 14, 2016

Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW, Christenson J, Egan D, Ornato JP, Weisfeldt ML, Stiell IG, Idris AH, Aufderheide TP, Dunford JV, Colella MR, Vilke GM, Brienza AM, Desvigne-Nickens P, Gray PC, Gray R, Seals N, Straight R, Dorian P; Resuscitation Outcomes Consortium Investigators. Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2016 May 5;374(18):1711-22. doi: 10.1056/NEJMoa1514204. Epub 2016 Apr 4.

Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess
Talan DA, Mower WR, Krishnadasan A, Abrahamian FM, Lovecchio F, Karras DJ, Steele MT, Rothman RE, Hoagland R, Moran GJ. Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess. N Engl J Med. 2016 Mar 3;374(9):823-32. doi: 10.1056/NEJMoa1507476.

Delivering safe and effective analgesia for management of renal colic in the emergency department: a double-blind, multigroup, randomised controlled trial
Pathan SA, Mitra B, Straney LD, Afzal MS, Anjum S, Shukla D, Morley K, Al Hilli SA, Al Rumaihi K, Thomas SH, Cameron PA. Delivering safe and effective analgesia for management of renal colic in the emergency department: a double-blind, multigroup, randomised controlled trial. Lancet. 2016 May 14;387(10032):1999-2007. doi: 10.1016/S0140-6736(16)00652-8. Epub 2016 Mar 16.

 

Epidemiology/Biostatistics Resource Person: Dr. Garth Hunte


April 7, 2016

A clinical decision instrument for 30-Day death after an emergency department visit for atrial fibrillation: the atrial fibrillation in the emergency room (AFTER) study
Atzema CL et al. A Clinical Decision Instrument for 30-Day Death After an Emergency Department Visit for Atrial Fibrillation: The Atrial Fibrillation in the Emergency Room (AFTER) Study. Ann Emerg Med. 2015 Dec; 66(6): 656-668

Reviewed Articles View Article Appraisal

 

Intravascular complications of central venous catheterization by insertion site
Parienti JJ, Mongardon N, Mégarbane B, Mira JP, Kalfon P, Gros A, Marqué S, Thuong M, Pottier V, Ramakers M, Savary B, Seguin A, Valette X, Terzi N, Sauneuf B, Cattoir V, Mermel LA, du Cheyron D; 3SITES Study Group. Intravascular Complications of Central Venous Catheterization by Insertion Site. N Engl J Med. 2015 Sep 24;373(13):1220-9.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Rob Stenstrom


March 3, 2016

A randomized controlled trial of intravenous haloperidol vs. intravenous metoclopramide for acute migraine therapy in the emergency department
Gaffigan ME, Bruner DI, Wason C, Pritchard A, Frumkin K. A randomized controlled trial of intravenous haloperidol vs. intravenous metoclopramide for acute migraine therapy in the emergency department. J Emerg Med. 2015 Sep;49(3):326-34.

Reviewed Articles View Article Appraisal

 

The validity of abdominal examination in blunt trauma patients with distracting injuries
Rostas J, Cason B, Simmons J, Frotan MA, Brevard SB, Gonzalez RP. The validity of abdominal examination in blunt trauma patients with distracting injuries. J Trauma Acute Care Surg. 2015 Jun;78(6):1095-100 ; discussion 1100 – 1.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Les Vertesi


Feb 4, 2016

CT within 6 hours of headache onset to rule out subarachnoid hemorrhage in nonacademic hospitals
Blok KM, Rinkel GJ, Majoie CB, Hendrikse J, Braaksma M, Tijssen CC, Wong YY, Hofmeijer J, Extercatte J, Kerklaan B, Schreuder TH, ten Holter S, Verheul F, Harlaar L, Pruissen DM, Kwa VI, Brouwers PJ, Remmers MJ, Schonewille WJ, Kruyt ND, Vergouwen MD. CT within 6 hours of headache onset to rule out subarachnoid hemorrhage in nonacademic hospitals. Neurology. 2015 May 12;84(19):1927-32. doi: 10.1212/WNL.0000000000001562. Epub 2015 Apr 10.

Reviewed Articles View Article Appraisal

 

Does a single dose of intravenous dexamethasone reduce symptoms in emergency department patients with low back pain and radiculopathy (SEBRA)? A double-blind randomised controlled trial
Balakrishnamoorthy R, Horgan I, Perez S, Steele MC, Keijzers GB. Does a single dose of intravenous dexamethasone reduce Symptoms in Emergency department patients with low Back pain and RAdiculopathy (SEBRA)? A double-blind randomised controlled trial. Emerg Med J. 2015 Jul;32(7):525-30. doi: 10.1136/emermed-2013-203490. Epub 2014 Aug 13.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. David Barbic


Jan 7, 2016

Trial of continuous or interrupted chest compressions during CPR
Nichol G, Leroux B, Wang H, Callaway CW, Sopko G, Weisfeldt M, Stiell I, Morrison LJ, Aufderheide TP, Cheskes S, Christenson J, Kudenchuk P, Vaillancourt C, Rea TD, Idris AH, Colella R, Isaacs M, Straight R, Stephens S, Richardson J, Condle J, Schmicker RH, Egan D, May S, Ornato JP; ROC Investigators. Trial of continuous or interrupted chest compressions during CPR. N Engl J Med. 2015 Dec 3;373(23):2203-14. doi: 10.1056/NEJMoa1509139. Epub 2015 Nov 9.

Reviewed Articles View Article Appraisal

 

Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay
Reichlin T, et al. Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay. CMAJ. 2015 May. 187(8). doi: 10.1503/cmaj.141349

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Riyad Abu-Laban


Dec 3, 2015

Naproxen With cyclobenzaprine, oxycodone/acetaminophen, or placebo for treating acute low back pain: a randomized clinical trial
Friedman BW, Dym AA, Davitt M, Holden L, Solorzano C, Esses D, Bijur PE, Gallagher EJ. Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA. 2015 Oct 20;314(15):1572-80. doi: 10.1001/jama.2015.13043

Reviewed Articles View Article Appraisal

 

FAST ultrasound examination as a predictor of outcomes after resuscitative thoracotomy: a prospective evaluation
Inaba, Kenji, Konstantinos Chouliaras, Scott Zakaluzny, Stuart Swadron, Thomas Mailhot, Dina Seif, Pedro Teixeira, et al. 2015. FAST ultrasound examination as a predictor of outcomes after resuscitative thoracotomy: a prospective evaluation. Annals of surgery, no. 3. doi:10.1097/SLA.0000000000001421.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Devin Harris


Nov 5, 2015

Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial
Pickard R, Starr K, MacLennan G, Lam T, Thomas R, Burr J, McPherson G, McDonald A, Anson K, N’Dow J, Burgess N, Clark T, Kilonzo M, Gillies K, Shearer K, Boachie C, Cameron S, Norrie J, McClinton S. Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial. Lancet. 2015 Jul 25;386(9991):341-9. doi: 10.1016/S0140-6736(15)60933-3. Epub 2015 May 18.

Reviewed Articles View Article Appraisal

 

Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial
Appelboam A, Reuben A, Mann C, Gagg J, Ewings P, Barton A, Lobban T, Dayer M, Vickery J, Benger J; REVERT trial collaborators. Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial. Lancet. 2015 Aug 24. pii: S0140-6736(15)61485-4. doi: 10.1016/S0140-6736(15)61485-4. [Epub ahead of print]

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Iain MacPhail


Oct 1, 2015

Adjunct prednisone therapy for patients with community acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial
Blum, Claudine Angela et al. Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet 2015 Apr 19;385(9977):1511-8. Epub 2015 Jan 19.

Reviewed Articles View Article Appraisal

 

Diltiazem vs. metoprolol in the management of atrial fibrillation or flutter with rapid ventricular rate in the emergency department
Fromm C, Suau SJ, Cohen V, Likourezos A, Jellinek-Cohen S, Rose J, Marshall J. Diltiazem vs. Metoprolol in the Management of Atrial Fibrillation or Flutter with Rapid Ventricular Rate in the Emergency Department. J Emerg Med. 2015 Aug;49(2):175-82. doi: 10.1016/j.jemermed.2015.01.014. Epub 2015 Apr 22.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Corinne Hohl


Sept 10, 2015

Randomized assessment of rapid endovascular treatment of ischemic stroke
Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA, Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Williams D, Bang OY, Baxter BW, Burns PA, Choe H, Heo JH, Holmstedt CA, Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn SI, Swartz RH, Barber PA, Coutts SB, Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill MD; ESCAPE Trial Investigators. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015 Mar 12;372(11):1019-30. Epub 2015 Feb 11.

Reviewed Articles View Article Appraisal

 

High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure
Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R; FLORALI Study Group; REVA Network. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015 Jun 4;372(23):2185-96. Epub 2015 May 17.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Frank Scheuermeyer


May 7, 2015

Emergency department corticosteroid use for allergy or anaphylaxis is not associate with decreased relapses
Grunau BE, Wiens MO, Rowe BH, McKay R, Li J, Yi TW, Stenstrom R, Schellenberg RR, Grafstein E, Scheuermeyer FX. Emergency department corticosteroid use for allergy or anaphylaxis is not associated with cecreased relapses. Ann Emerg Med. 2015 Mar 25. pii: S0196-0644(15)00190-0. doi: 10.1016/j.annemergmed.2015.03.003. [Epub ahead of print]

Reviewed Articles View Article Appraisal

 

Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit:
a randomized trial

Parshuram CS, Amaral AC, Ferguson ND, Baker GR, Etchells EE, Flintoft V, Granton J, Lingard L, Kirpalani H, Mehta S, Moldofsky H, Scales DC, Stewart TE, Willan AR, Friedrich JO; Canadian Critical Care Trials Group. Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit: a randomized trial. CMAJ. 2015 Mar 17;187(5):321-9. doi: 10.1503/cmaj.140752. Epub 2015 Feb 9.
Background reading: Resident duty-hour reform: moving beyond “change for change’s sake”

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Jeff Brubacher


April 2, 2015

Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma – the PROPPR randomized clinical trial
Holcomb JB et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma – the PROPPR randomized clinical trial. JAMA. 2015;313(5):471-482. doi:10.1001/jama.2015.12.

Reviewed Articles View Article Appraisal + Addendum


Treatment of pulmonary embolism with rivaroxaban: outcomes by simplified pulmonary embolism severity index score from a post hoc analysis of the EINSTEIN PE study
Fermann GJ, Erkens PM, Prins MH, Wells PS, Pap ÁF, Lensing AW. Treatment of pulmonary embolism with rivaroxaban: outcomes by simplified pulmonary embolism severity index score from a post hoc analysis of the EINSTEIN PE study. Acad Emerg Med. 2015 Mar;22(3):299-307. doi: 10.1111/acem.12615. Epub 2015 Feb 25.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Riyad Abu-Laban


March 5, 2015

A comparison of acute treatment regimens for migraine in the emergency department
Bachur RG, Monuteaux MC, Neuman M. A comparison of acute treatment regimens for migraine in the emergency department. Pediatrics. 2015 Feb;135(2):232-8.

Reviewed Articles View Article Appraisal

 

Nebulized fentanyl vs intravenous morphine for ED patients with acute limb pain: a randomized clinical trial
Farahmand S, Shiralizadeh S, Talebian MT, Bagheri-Hariri S, Arbab M, Basirghafouri H, Saeedi M, Sedaghat M, Mirzababai H. Nebulized fentanyl vs intravenous morphine for ED patients with acute limb pain: a randomized clinical trial. Am J Emerg Med. 2014 Sep;32(9):1011-5.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. John Tallon


February 12, 2015

Traumatic lacerations: what are the risks for infection and has the ‘golden period’ of laceration care disappeared?
Quinn JV1, Polevoi SK, Kohn MA. Traumatic lacerations: what are the risks for infection and has the ‘golden period’ of laceration care disappeared? Emerg Med J. 2014 Feb;31(2):96-100. Epub 2013 Jan 12.

Reviewed Articles View Article Appraisal

 

Ultrasonography versus computed tomography for suspected nephrolithiasis
Smith-Bindman R, Aubin C, Bailitz J, Bengiamin R, Camargo C, et al. Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis. New England Journal of Medicine. 2014 Sep 18; 371:1100-1110.

Reviewed Articles View Article Appraisal

 

Epidemiology/Biostatistics Resource Person: Dr. Rob Stenstrom


January 8, 2015

Outcomes after out-of-hospital cardiac arrest treated by basic vs advanced life support
Sanghavi P, Jena AB, Newhouse JP, Zaslavsky AM. Outcomes After Out-of-Hospital Cardiac Arrest Treated by Basic vs Advanced Life Support. JAMA Intern Med. 2014 Nov 24. DOI: 10.1001/jamainternmed.2014.5420. [Epub ahead of print]

Reviewed Articles View Article Appraisal

 

Delayed sequence intubation: a prospective observational study
Weingart SD, Trueger NS, Wong N, Scofi J, Singh N, Rudolph SS. Delayed Sequence Intubation: A Prospective Observational Study. Ann Emerg Med. 2014 Oct 23. pii: S0196-0644(14)01365-1. DOI: 10.1016/j.annemergmed.2014.09.025. [Epub ahead of print]

Reviewed Articles View Article Appraisal

 

January Epidemiology/Biostatistics Resource Person: Corinne Hohl


December 5, 2014

Operative versus nonoperative treatment in the management of midshaft clavicular fractures: a meta-analysis of randomized controlled trials
Xu J, Xu L, Xu W, Gu Y, Xu J. Operative versus nonoperative treatment in the management of midshaft clavicular fractures: a meta-analysis of randomized controlled trials. J Shoulder Elbow Surg. 2014 Feb;23(2):173-81. doi: 10.1016/j.jse.2013.06.025. Epub 2013 Oct 12.

Reviewed Articles View Article Appraisal

 

Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis
Chatterjee S, Chakraborty A, Weinberg I, Kadakia M, Wilensky RL, Sardar P, Kumbhani DJ, Mukherjee D, Jaff MR, Giri J. Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis. JAMA. 2014 Jun 18;311(23):2414-21. doi: 10.1001/jama.2014.5990

Reviewed Articles View Article Appraisal

 

December Epidemiology/Biostatistics Resource Person: Iain MacPhail


November 6, 2014

Lower versus higher hemoglobin threshold for transfusion in septic shock
Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, Johansson PI, Aneman A, Vang ML, Winding R, Nebrich L, Nibro HL, Rasmussen BS, Lauridsen JR, Nielsen JS, Oldner A, Pettilä V, Cronhjort MB, Andersen LH, Pedersen UG, Reiter N, Wiis J, White JO, Russell L, Thornberg KJ, Hjortrup PB, Müller RG, Møller MH, Steensen M, Tjäder I, Kilsand K, Odeberg-Wernerman S, Sjøbø B, Bundgaard H, Thyø MA, Lodahl D, Mærkedahl R, Albeck C, Illum D, Kruse M, Winkel P, Perner A; TRISS Trial Group; Scandinavian Critical Care Trials Group. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med. 2014 Oct 9;371(15):1381-91. doi: 10.1056/NEJMoa1406617

Reviewed Articles View Article Appraisal

 

Ambulatory management of large spontaneous pneumothorax with
pigtail catheters

Voisin F, Sohier L, Rochas Y, Kerjouan M, Ricordel C, Belleguic C, Desrues B, Jouneau S. Ambulatory management of large spontaneous pneumothorax with pigtail catheters. Ann Emerg Med. 2014 Sep;64(3):222-8. doi: 10.1016/j.annemergmed.2013.12.017

Reviewed Articles View Article Appraisal

 

November Epidemiology/Biostatistics Resource Person: Les Vertesi


October 2, 2014

Antiemetic use for nausea and vomiting in adult emergency department patients: randomized controlled trial comparing ondansetron, metoclopramide, and placebo
Egerton-Warburton D, Meek R, Mee MJ, Braitberg G. Antiemetic Use for Nausea and Vomiting in Adult Emergency Department Patients: Randomized Controlled Trial Comparing Ondansetron, Metoclopramide, and Placebo. Ann Emerg Med. 2014 May 9. pii: S0196-0644(14)00223-6. DOI: 10.1016/j.annemergmed.2014.03.017

Reviewed Articles View Article Appraisal

 

Comparison of PECARN, CATCH, and CHALICE rules for children with minor head injury: a prospective cohort study
Easter JS, Bakes K, Dhaliwal J, Miller M, Caruso E, Haukoos JS. Comparison of PECARN, CATCH, and CHALICE rules for children with minor head injury: a prospective cohort study. Ann Emerg Med. 2014 Aug;64(2):145-52, 152.e1-5. DOI: 10.1016/j.annemergmed.2014.01.030. Epub 2014 Mar 11.

Reviewed Articles View Article Appraisal

 

October Epidemiology/Biostatistics Resource Person: David Barbic


September 4, 2014

Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial
He J, Zhang Y, Xu T, Zhao Q, Wang D, Chen CS, Tong W, Liu C, Xu T, Ju Z, Peng Y, Peng H, Li Q, Geng D, Zhang J, Li D, Zhang F, Guo L, Sun Y, Wang X, Cui Y, Li Y, Ma D, Yang G, Gao Y, Yuan X, Bazzano LA, Chen J; CATIS Investigators. Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke the CATIS randomized clinical trial. JAMA. 2014 Feb 5;311(5):479-89. DOI: 10.1001/jama.2013.282543

Reviewed Articles  View Article Appraisal

 

A case-controlled comparison of thrombolysis outcomes between wake-up and known time of onset ischemic stroke patients
Manawadu D, Bodla S, Jarosz J, Keep J, Kalra L. A case-controlled comparison of thrombolysis outcomes between wake-up and known time of onset ischemic stroke patientStroke. 2013 Aug;44(8):2226-31. DOI: 10.1161/STROKEAHA.111.000757

Reviewed Articles  View Article Appraisal

 

September Epidemiology/Biostatistics Resource Person: Riyad Abu-Laban


June 5, 2014

Derivation and validation of a clinical prediction rule for uncomplicated ureteral stone—the STONE score: retrospective and prospective observational cohort studies
Moore CL, Bomann S, Daniels B, Luty S, Molinaro A, Singh D, Gross CP. Derivation and validation of a clinical prediction rule for uncomplicated ureteral stone—the STONE score: retrospective and prospective observational cohort studies. BMJ. 2014 March;348:g2191.

Incidence of clinically important biphasic reactions in emergency department patients with allergic reactions or anaphylaxis
Grunau BE, Li J, Yi TW, Stenstrom R, Grafstein E, Wiens MO, Schellenberg RR, Scheuermeyer FX. Incidence of clinically important biphasic reactions in emergency department patients with allergic reactions or anaphylaxis. Ann Emerg Med. 2014 Jun;63(6):736-744.e2. Epub 2013 Nov 13.

 

June Epidemiology/Biostatistics Resource Person: Garth Hunte


May 1, 2014

An ED scribe program is able to improve throughput time and patient satisfaction
Bastani A, Shaqiri B, Palomba K, Bananno D, Anderson W. An ED scribe program is able to improve throughput time and patient satisfaction. Am J Emerg Med. 2014 May;32(5):399-402. Epub 2014 Mar 15
Reviewed Articles  View Article Appraisal

 

Topical Tetracaine Used for 24 Hours Is Safe and Rated Highly Effective by Patients for the Treatment of Pain Caused by Corneal Abrasions: A Double-blind, Randomized Clinical Trial
Waldman N1, Densie IK, Herbison P. Topical Tetracaine Used for 24 Hours Is Safe and Rated Highly Effective by Patients for the Treatment of Pain Caused by Corneal Abrasions: A Double-blind, Randomized Clinical Trial. Acad Emerg Med. 2014 Apr;21(4):374-382.
Reviewed Articles View Article Appraisal

 

May Epidemiology/Biostatistics Resource Person: Frank Scheuermeyer

 


April 3, 2014

Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study
Righini M, Van Es J, Den Exter PL, et al. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. JAMA. 2014;311(11):1117-1124. doi:10.1001/jama.2014.2135
Reviewed Articles View Article Appraisal

 

A randomized trial of protocol-based care for early septic shock
The ProCESS Investigators. A Randomized Trial of Protocol-Based Care for Early Septic Shock. N Engl J Med. 2014 Mar 18. [Epub ahead of print]. DOI: 10.1056/NEJMoa1401602

Reviewed Articles View Article Appraisal

 

April Epidemiology/Biostatistics Resource Person: Riyad Abu-Laban


March 6, 2014

Randomized clinical trial of efficacy and safety of a single 2-mg intravenous dose of hydromorphone versus usual care in the management of acute pain
Chang AK et al. Randomized Clinical Trial of Efficacy and Safety of a Single 2-mg Intravenous Dose of Hydromorphone Versus Usual Care in the Management of Acute Pain. Acad Emerg Med. 2013; 20, 185–192.
Reviewed Articles View Article Appraisal

 

Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage
Anderson et al. Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage. NEJM. 2014; 368(25): 2355-2365.
Reviewed Articles View Article Appraisal

 

March Epidemiology/Biostatistics Resource Person: John Tallon


February 6, 2014

Effect of cognitive activity level on duration of post-concussion symptoms 
Brown NJ et al. Effect of Cognitive Activity Level on Duration of Post- Concussion Symptoms. Pediatrics. 2014; 133(2): 1-6.
Reviewed Articles View Article Appraisal

 

Immediate and delayed traumatic intracranial hemorrhage in patients with head trauma and preinjury warfarin or clopidogrel use

Nishijima DK et al. Immediate and delayed traumatic intracranial hemorrhage in patients with head trauma and preinjury warfarin or clopidogrel use. Ann Emerg Med. 2012 Jun;59(6):460-8. Cited in: PubMed; PMID 22626015.
Reviewed Articles View Article Appraisal

 

February Epidemiology/Biostatistics Resource Person: Ka Wai Cheung